6nvf: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 3: Line 3:
<StructureSection load='6nvf' size='340' side='right'caption='[[6nvf]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='6nvf' size='340' side='right'caption='[[6nvf]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6nvf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NVF FirstGlance]. <br>
<table><tr><td colspan='2'>[[6nvf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NVF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L5A:(4-{[(1S,2S)-2-(carboxymethyl)cyclopentyl]methyl}phenyl)acetic+acid'>L5A</scene>, <scene name='pdbligand=L5J:(4-{[(1R,2R)-2-(carboxymethyl)cyclopentyl]methyl}phenyl)acetic+acid'>L5J</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.989&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6cve|6cve]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L5A:(4-{[(1S,2S)-2-(carboxymethyl)cyclopentyl]methyl}phenyl)acetic+acid'>L5A</scene>, <scene name='pdbligand=L5J:(4-{[(1R,2R)-2-(carboxymethyl)cyclopentyl]methyl}phenyl)acetic+acid'>L5J</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dethiobiotin_synthase Dethiobiotin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.3 6.3.3.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nvf OCA], [https://pdbe.org/6nvf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nvf RCSB], [https://www.ebi.ac.uk/pdbsum/6nvf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nvf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nvf OCA], [http://pdbe.org/6nvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nvf RCSB], [http://www.ebi.ac.uk/pdbsum/6nvf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nvf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU]] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref>
[https://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref>  
 
==See Also==
*[[Dethiobiotin synthetase 3D structures|Dethiobiotin synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dethiobiotin synthase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bruning, J B]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Polyak, S W]]
[[Category: Bruning JB]]
[[Category: Thompson, A P]]
[[Category: Polyak SW]]
[[Category: Wegener, K L]]
[[Category: Thompson AP]]
[[Category: Enzyme]]
[[Category: Wegener KL]]
[[Category: Ligase]]
[[Category: Nucleotide triphosphate binding]]
[[Category: Synthetase]]
[[Category: Transferase]]

Latest revision as of 10:00, 11 October 2023

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8

Structural highlights

6nvf is a 4 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.989Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BIOD_MYCTU Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.[1]

See Also

References

  1. ↑ Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 2010 Aug 10;49(31):6746-60. PMID:20565114 doi:10.1021/bi902097j

6nvf, resolution 1.99Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=6nvf&oldid=3903530"