1ndv: Difference between revisions
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'''Crystal Structure of Adenosine Deaminase complexed with FR117016''' | '''Crystal Structure of Adenosine Deaminase complexed with FR117016''' | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Kinoshita, T.]] | [[Category: Kinoshita, T.]] | ||
[[Category: | [[Category: Beta barrel]] | ||
[[Category: | [[Category: Inhibitor-induced conformational change]] | ||
[[Category: | [[Category: Structure-based drug design]] | ||
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Revision as of 02:25, 3 May 2008
Crystal Structure of Adenosine Deaminase complexed with FR117016
OverviewOverview
We disclose herein the rapid discovery of the first highly potent (Ki = 7.7 nM) non-nucleoside adenosine deaminase (ADA) inhibitor based on the rational hybridization of two structurally distinct leads. Two micromolar inhibitors were discovered by a parallel rational design and random screening program, and individual crystal structures of bovine ADA in complexation with these inhibitors revealed several unknown binding sites and distinct binding modes. Using this information as the starting point, highly effective lead hybridization was achieved in only two structure-based drug design iterations. The conceptual approach illustrated by this example promises to be broadly useful in the search for new chemical entities and can contribute greatly to improve the overall efficiency and speed of drug discovery.
About this StructureAbout this Structure
1NDV is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
ReferenceReference
A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization., Terasaka T, Kinoshita T, Kuno M, Nakanishi I, J Am Chem Soc. 2004 Jan 14;126(1):34-5. PMID:14709046 Page seeded by OCA on Sat May 3 02:25:00 2008