6mp1: Difference between revisions

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<StructureSection load='6mp1' size='340' side='right'caption='[[6mp1]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
<StructureSection load='6mp1' size='340' side='right'caption='[[6mp1]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6mp1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MP1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6mp1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MP1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.211&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mp1 OCA], [http://pdbe.org/6mp1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mp1 RCSB], [http://www.ebi.ac.uk/pdbsum/6mp1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mp1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mp1 OCA], [https://pdbe.org/6mp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mp1 RCSB], [https://www.ebi.ac.uk/pdbsum/6mp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mp1 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/TYRP1_MOUSE TYRP1_MOUSE]] Defects in Tyrp1 are the cause of the brown (b) phenotype. Brown mice have a brown or hypopigmented coat.<ref>PMID:2245916</ref>
[https://www.uniprot.org/uniprot/TYRP1_MOUSE TYRP1_MOUSE] Defects in Tyrp1 are the cause of the brown (b) phenotype. Brown mice have a brown or hypopigmented coat.<ref>PMID:2245916</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TYRP1_MOUSE TYRP1_MOUSE]] Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid (PubMed:7813420). May regulate or influence the type of melanin synthesized (PubMed:7813420, PubMed:2245916). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (PubMed:1537333).<ref>PMID:1537333</ref> <ref>PMID:2245916</ref> <ref>PMID:7813420</ref>
[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.[https://www.uniprot.org/uniprot/TYRP1_MOUSE TYRP1_MOUSE] Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid (PubMed:7813420). May regulate or influence the type of melanin synthesized (PubMed:7813420, PubMed:2245916). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (PubMed:1537333).<ref>PMID:1537333</ref> <ref>PMID:2245916</ref> <ref>PMID:7813420</ref> [https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6mp1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6mp1" style="background-color:#fffaf0;"></div>
==See Also==
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Birnbaum, M E]]
[[Category: Birnbaum ME]]
[[Category: Clancy-Thompson, E]]
[[Category: Clancy-Thompson E]]
[[Category: Devlin, C A]]
[[Category: Devlin CA]]
[[Category: Dougan, S K]]
[[Category: Dougan SK]]
[[Category: Immune system]]
[[Category: Mhc]]

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