6dyn: Difference between revisions
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<StructureSection load='6dyn' size='340' side='right'caption='[[6dyn]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='6dyn' size='340' side='right'caption='[[6dyn]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6dyn]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6dyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DYN FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.102Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dyn OCA], [https://pdbe.org/6dyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dyn RCSB], [https://www.ebi.ac.uk/pdbsum/6dyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dyn ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/EBO_DROME EBO_DROME] Nonribosomal peptide synthase which is required for the regulation of histamine and dopamine levels in various tissues through their condensation with beta-alanine (PubMed:12900414, PubMed:19715698, PubMed:25229196, PubMed:30705105). In epithelial glial cells, plays an essential role in the inactivation of histamine, the main neurotransmitter in the optical nerve system, by catalyzing the conversion of histamine into carcinine (PubMed:5782111, PubMed:12486147, PubMed:12900414, PubMed:25229196, PubMed:30705105). In the cuticle, catalyzes the condensation of beta-alanine with dopamine to form beta-alanyl-dopamine (NBAD), a metabolite involved in the pigmentation and sclerotization of the insect cuticle (PubMed:8580497, PubMed:11934851). Also, regulates the cuticular hydrocarbon composition in females (PubMed:31118901). Acts downstream of the body clock to regulate circadian behavioral rhythms (PubMed:17678856). Can also condense beta-alanine with biogenic amines tyramine, octopamine, and serotonin in vitro (PubMed:12900414, PubMed:19715698).<ref>PMID:11934851</ref> <ref>PMID:12486147</ref> <ref>PMID:12900414</ref> <ref>PMID:17678856</ref> <ref>PMID:19715698</ref> <ref>PMID:25229196</ref> <ref>PMID:30705105</ref> <ref>PMID:31118901</ref> <ref>PMID:5782111</ref> <ref>PMID:8580497</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Drosophila melanogaster]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cryle | [[Category: Cryle MJ]] | ||
[[Category: Hansen | [[Category: Hansen MH]] | ||
[[Category: Izore | [[Category: Izore T]] | ||
[[Category: Jackson | [[Category: Jackson CJ]] | ||
[[Category: Kaczmarski | [[Category: Kaczmarski JA]] | ||
[[Category: Tailhades | [[Category: Tailhades J]] | ||