6ds7: Difference between revisions

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<StructureSection load='6ds7' size='340' side='right'caption='[[6ds7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6ds7' size='340' side='right'caption='[[6ds7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ds7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DS7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ds7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DS7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mhuD, Rv3592 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Heme_oxygenase_(biliverdin-producing) Heme oxygenase (biliverdin-producing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.18 1.14.14.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ds7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ds7 OCA], [https://pdbe.org/6ds7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ds7 RCSB], [https://www.ebi.ac.uk/pdbsum/6ds7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ds7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ds7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ds7 OCA], [http://pdbe.org/6ds7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ds7 RCSB], [http://www.ebi.ac.uk/pdbsum/6ds7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ds7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MHUD_MYCTU MHUD_MYCTU]] Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.  
[https://www.uniprot.org/uniprot/MHUD_MYCTU MHUD_MYCTU] Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
 
==See Also==
*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Chao, A]]
[[Category: Chao A]]
[[Category: Goulding, C W]]
[[Category: Goulding CW]]
[[Category: Cell wall]]
[[Category: Heme binding]]
[[Category: Heme catabolic process]]
[[Category: Metal ion binding]]
[[Category: Monooxygenase activity]]
[[Category: Oxidation reduction process]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase activity]]
[[Category: Plasma membrane]]

Latest revision as of 09:13, 11 October 2023

Crystal structure of MhuD R26S mutant with two hemes bound per active siteCrystal structure of MhuD R26S mutant with two hemes bound per active site

Structural highlights

6ds7 is a 2 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MHUD_MYCTU Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.

See Also

6ds7, resolution 1.90Å

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