5l4x: Difference between revisions

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==Crystal structure of FimH lectin domain in complex with 4-Deoxy-Heptylmannoside==
==Crystal structure of FimH lectin domain in complex with 4-Deoxy-Heptylmannoside==
<StructureSection load='5l4x' size='340' side='right' caption='[[5l4x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5l4x' size='340' side='right'caption='[[5l4x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5l4x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L4X FirstGlance]. <br>
<table><tr><td colspan='2'>[[5l4x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L4X FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6KU:4-Deoxy-Heptylmannoside'>6KU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fimH, b4320, JW4283 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6KU:heptyl+4-deoxy-4-deoxy-alpha-D-mannopyranoside'>6KU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4x OCA], [http://pdbe.org/5l4x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l4x RCSB], [http://www.ebi.ac.uk/pdbsum/5l4x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4x OCA], [https://pdbe.org/5l4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l4x RCSB], [https://www.ebi.ac.uk/pdbsum/5l4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.  
[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
 
==See Also==
*[[Adhesin 3D structures|Adhesin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Ernst, B]]
[[Category: Large Structures]]
[[Category: Jakob, R P]]
[[Category: Ernst B]]
[[Category: Maier, T]]
[[Category: Jakob RP]]
[[Category: Rabbani, S]]
[[Category: Maier T]]
[[Category: Zihlmann, P]]
[[Category: Rabbani S]]
[[Category: Carbohydrate]]
[[Category: Zihlmann P]]
[[Category: Cell adhesion]]
[[Category: Fimh]]
[[Category: Lectin]]
[[Category: Mannose]]
[[Category: Sugar binding protein]]
[[Category: Type 1 pilus]]
[[Category: Urinary tract infection]]
[[Category: Uti]]

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