1nan: Difference between revisions

Revision as of 02:18, 3 May 2008

MCH CLASS I H-2KB MOLECULE COMPLEXED WITH PBM1 PEPTIDE

OverviewOverview

T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2K(b) major histocompatibility complex molecule at a 2.7 A resolution, and compared it with the BM3.3 TCR bound to the H-2K(b) molecule loaded with a peptide that has no primary sequence identity with VSV8. Comparison of these structures showed that the BM3.3 TCR complementarity-determining region (CDR) 3alpha could undergo rearrangements to adapt to structurally different peptide residues. Therefore, CDR3 loop flexibility helps explain TCR binding cross-reactivity.

About this StructureAbout this Structure

1NAN is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

CDR3 loop flexibility contributes to the degeneracy of TCR recognition., Reiser JB, Darnault C, Gregoire C, Mosser T, Mazza G, Kearney A, van der Merwe PA, Fontecilla-Camps JC, Housset D, Malissen B, Nat Immunol. 2003 Mar;4(3):241-7. Epub 2003 Feb 3. PMID:12563259 Page seeded by OCA on Sat May 3 02:18:01 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1nan.gif|left|200px]]
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-|GENE= H2-K ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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 '''MCH CLASS I H-2KB MOLECULE COMPLEXED WITH PBM1 PEPTIDE'''
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 [[Category: Mosser, T.]]
 [[Category: Reiser, J B.]]
-[[Category: alloreactivity]]
+[[Category: Alloreactivity]]
-[[Category: class i mhc]]
+[[Category: Class i mhc]]
-[[Category: crossreactivity]]
+[[Category: Crossreactivity]]
-[[Category: h-2kb]]
+[[Category: H-2kb]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:18:01 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:27:43 2008''