6d3f: Difference between revisions

<table><tr><td colspan='2'>[[6d3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D3F OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6D3F FirstGlance]. <br>

</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6d3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d3f OCA], [http://pdbe.org/6d3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d3f RCSB], [http://www.ebi.ac.uk/pdbsum/6d3f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d3f ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/PTPRE_HUMAN PTPRE_HUMAN]] Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).  Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity).  Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).  

[[Category: Austin, B P]]

[[Category: Burke, T R]]

[[Category: Dyas, B K]]

[[Category: Lountos, G T]]

[[Category: Raran-Kurussi, S]]

[[Category: Ulrich, R G]]

[[Category: Waugh, D S]]

[[Category: Zhao, B M]]

[[Category: Phosphatase]]