1na7: Difference between revisions

Revision as of 02:17, 3 May 2008

Crystal structure of the catalytic subunit of human protein kinase CK2

OverviewOverview

The three-dimensional crystal structure of the triple-point mutant of the catalytic subunit of human protein kinase CK2alpha has been determined at 2.4 A resolution. Microcrystals of mutant CK2 catalytic subunit were obtained by a protein-crystallization method based on thin-film nanotechnology. These microcrystals (of about 20 micro m in diameter) were used for diffraction data collection by means of the microfocus beamline at the ESRF synchrotron. A comparison between the human protein kinase CK2alpha and the corresponding enzyme from a lower organism (Zea mays) is made.

About this StructureAbout this Structure

1NA7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2., Pechkova E, Zanotti G, Nicolini C, Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2133-9. Epub 2003, Nov 27. PMID:14646071 Page seeded by OCA on Sat May 3 02:17:09 2008

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OCA

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 [[Image:1na7.gif|left|200px]]
- {{Structure
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-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1na7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1na7 OCA], [http://www.ebi.ac.uk/pdbsum/1na7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1na7 RCSB]</span>
-}}
 '''Crystal structure of the catalytic subunit of human protein kinase CK2'''
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 [[Category: Pechkova, E.]]
 [[Category: Zanotti, G.]]
-[[Category: ck2]]
+[[Category: Ck2]]
-[[Category: microcrystal]]
+[[Category: Microcrystal]]
-[[Category: microfocus esrf]]
+[[Category: Microfocus esrf]]
-[[Category: protein kinase]]
+[[Category: Protein kinase]]
-[[Category: thin-film nanotechnology]]
+[[Category: Thin-film nanotechnology]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 02:17:09 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:27:32 2008''