6c55: Difference between revisions

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<StructureSection load='6c55' size='340' side='right'caption='[[6c55]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
<StructureSection load='6c55' size='340' side='right'caption='[[6c55]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c55]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staab Staab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C55 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c55]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_RF122 Staphylococcus aureus RF122]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C55 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EKA:[cyclohexyl(hydroxy)amino](oxo)acetic+acid'>EKA</scene>, <scene name='pdbligand=EKD:(cyclohexylamino)(oxo)acetic+acid'>EKD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ilvC, SAB1941 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273036 STAAB])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EKA:[cyclohexyl(hydroxy)amino](oxo)acetic+acid'>EKA</scene>, <scene name='pdbligand=EKD:(cyclohexylamino)(oxo)acetic+acid'>EKD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketol-acid_reductoisomerase Ketol-acid reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.86 1.1.1.86] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c55 OCA], [https://pdbe.org/6c55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c55 RCSB], [https://www.ebi.ac.uk/pdbsum/6c55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c55 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c55 OCA], [http://pdbe.org/6c55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c55 RCSB], [http://www.ebi.ac.uk/pdbsum/6c55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c55 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ILVC_STAAB ILVC_STAAB]] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.  
[https://www.uniprot.org/uniprot/ILVC_STAAB ILVC_STAAB] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ketol-acid reductoisomerase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Staab]]
[[Category: Staphylococcus aureus RF122]]
[[Category: Guddat, L W]]
[[Category: Guddat LW]]
[[Category: Kandale, A]]
[[Category: Kandale A]]
[[Category: McGeary, R P]]
[[Category: McGeary RP]]
[[Category: Patel, K M]]
[[Category: Patel KM]]
[[Category: Schenk, G]]
[[Category: Schenk G]]
[[Category: Schmbri, M]]
[[Category: Schmbri M]]
[[Category: You, L]]
[[Category: You L]]
[[Category: Zheng, S]]
[[Category: Zheng S]]
[[Category: Inhibitor]]
[[Category: Oxidoreductase]]

Latest revision as of 17:56, 4 October 2023

Crystal structure of Staphylococcus aureus Ketol-acid Reductosimerrase with hydroxyoxamate inhibitor 3Crystal structure of Staphylococcus aureus Ketol-acid Reductosimerrase with hydroxyoxamate inhibitor 3

Structural highlights

6c55 is a 2 chain structure with sequence from Staphylococcus aureus RF122. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.09Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ILVC_STAAB Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

See Also

6c55, resolution 2.09Å

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