6c2n: Difference between revisions

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<StructureSection load='6c2n' size='340' side='right'caption='[[6c2n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='6c2n' size='340' side='right'caption='[[6c2n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus_subtype_1a Hepatitis c virus subtype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C2N FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_C_virus_genotype_1a Hepatitis C virus genotype 1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C2N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TSV:(2R,6S,12Z,13AS,14AR,16AS)-6-[(TERT-BUTOXYCARBONYL)AMINO]-14A-[(CYCLOPROPYLSULFONYL)CARBAMOYL]-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-2-YL+4-FLUORO-2H-ISOINDOLE-2-CARBOXYLATE'>TSV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.802&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c2n OCA], [http://pdbe.org/6c2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c2n RCSB], [http://www.ebi.ac.uk/pdbsum/6c2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c2n ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TSV:(2R,6S,12Z,13AS,14AR,16AS)-6-[(TERT-BUTOXYCARBONYL)AMINO]-14A-[(CYCLOPROPYLSULFONYL)CARBAMOYL]-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13A,14,14A,15,16,16A-HEXADECAHYDROCYCLOPROPA[E]PYRROLO[1,2-A][1,4]DIAZACYCLOPENTADECIN-2-YL+4-FLUORO-2H-ISOINDOLE-2-CARBOXYLATE'>TSV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c2n OCA], [https://pdbe.org/6c2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c2n RCSB], [https://www.ebi.ac.uk/pdbsum/6c2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c2n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A8DG50_9HEPC A8DG50_9HEPC]
==See Also==
*[[Virus protease 3D structures|Virus protease 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hepatitis c virus subtype 1a]]
[[Category: Hepatitis C virus genotype 1a]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Matthew, A N]]
[[Category: Matthew AN]]
[[Category: Schiffer, C A]]
[[Category: Schiffer CA]]
[[Category: Drug resistance]]
[[Category: Hepatitis c virus]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Ns3/4a protease]]
[[Category: Protease inhibitor]]

Latest revision as of 17:55, 4 October 2023

Crystal structure of HCV NS3/4A double mutant variant Y56H/D168A in complex with danoprevirCrystal structure of HCV NS3/4A double mutant variant Y56H/D168A in complex with danoprevir

Structural highlights

6c2n is a 1 chain structure with sequence from Hepatitis C virus genotype 1a. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.802Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A8DG50_9HEPC

See Also

6c2n, resolution 1.80Å

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