5vsv: Difference between revisions
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<StructureSection load='5vsv' size='340' side='right'caption='[[5vsv]], [[Resolution|resolution]] 2.21Å' scene=''> | <StructureSection load='5vsv' size='340' side='right'caption='[[5vsv]], [[Resolution|resolution]] 2.21Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5vsv]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5vsv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5uzo 5uzo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VSV FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8KY:{2-CHLORO-5-[({2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}CARBAMOYL)AMINO]PHENOXY}ACETIC+ACID'>8KY</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.205Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8KY:{2-CHLORO-5-[({2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}CARBAMOYL)AMINO]PHENOXY}ACETIC+ACID'>8KY</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vsv OCA], [https://pdbe.org/5vsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vsv RCSB], [https://www.ebi.ac.uk/pdbsum/5vsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vsv ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/A0A127ELD1_CLOPF A0A127ELD1_CLOPF] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | ||
==See Also== | ==See Also== | ||
| Line 17: | Line 15: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Clostridium perfringens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Anderson | [[Category: Anderson WF]] | ||
[[Category: Gollapalli DR]] | |||
[[Category: Gollapalli | [[Category: Gu M]] | ||
[[Category: Gu | [[Category: Hedstrom L]] | ||
[[Category: Hedstrom | [[Category: Joachimiak A]] | ||
[[Category: Joachimiak | [[Category: Kim Y]] | ||
[[Category: Kim | [[Category: Makowska-Grzyska M]] | ||
[[Category: Makowska-Grzyska | [[Category: Maltseva N]] | ||
[[Category: Maltseva | [[Category: Mulligan R]] | ||
[[Category: Mulligan | |||
Latest revision as of 16:57, 4 October 2023
Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P225Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P225
Structural highlights
FunctionA0A127ELD1_CLOPF Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] See Also |
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