1n69: Difference between revisions
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'''Crystal structure of human saposin B''' | '''Crystal structure of human saposin B''' | ||
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[[Category: Prive, G G.]] | [[Category: Prive, G G.]] | ||
[[Category: Whitelegge, J P.]] | [[Category: Whitelegge, J P.]] | ||
[[Category: | [[Category: Glycosphingolipid activator protein]] | ||
[[Category: | [[Category: Lipid binding protein]] | ||
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Revision as of 02:08, 3 May 2008
Crystal structure of human saposin B
OverviewOverview
Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from membranes, forming soluble protein-lipid complexes that are recognized by arylsulfatase A. The crystal structure of human saposin B reveals an unusual shell-like dimer consisting of a monolayer of alpha-helices enclosing a large hydrophobic cavity. Although the secondary structure of saposin B is similar to that of the known monomeric members of the saposin-like superfamily, the helices are repacked into a different tertiary arrangement to form the homodimer. A comparison of the two forms of the saposin B dimer suggests that extraction of target lipids from membranes involves a conformational change that facilitates access to the inner cavity.
About this StructureAbout this Structure
1N69 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of saposin B reveals a dimeric shell for lipid binding., Ahn VE, Faull KF, Whitelegge JP, Fluharty AL, Prive GG, Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):38-43. Epub 2002 Dec 23. PMID:12518053 Page seeded by OCA on Sat May 3 02:08:52 2008