1n4y: Difference between revisions
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{{STRUCTURE_1n4y| PDB=1n4y | SCENE= }} | |||
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'''REFINED STRUCTURE OF KISTRIN''' | '''REFINED STRUCTURE OF KISTRIN''' | ||
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==About this Structure== | ==About this Structure== | ||
1N4Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry | 1N4Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1kst 1kst]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Lazarus, R A.]] | [[Category: Lazarus, R A.]] | ||
[[Category: Wagner, G.]] | [[Category: Wagner, G.]] | ||
[[Category: | [[Category: Beta]] | ||
[[Category: | [[Category: Blood coagulation]] | ||
[[Category: | [[Category: Rgd]] | ||
[[Category: | [[Category: Venom]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:06:09 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 02:06, 3 May 2008
REFINED STRUCTURE OF KISTRIN
OverviewOverview
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.
About this StructureAbout this Structure
1N4Y is a Single protein structure of sequence from Calloselasma rhodostoma. This structure supersedes the now removed PDB entry 1kst. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:1862345 Page seeded by OCA on Sat May 3 02:06:09 2008