5kw2: Difference between revisions
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<StructureSection load='5kw2' size='340' side='right'caption='[[5kw2]], [[Resolution|resolution]] 2.76Å' scene=''> | <StructureSection load='5kw2' size='340' side='right'caption='[[5kw2]], [[Resolution|resolution]] 2.76Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5kw2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KW2 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5kw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KW2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6XQ:(3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic+acid'>6XQ</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.76Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6XQ:(3~{S})-3-cyclopropyl-3-[2-[1-[2-[2,2-dimethylpropyl-(6-methylpyridin-2-yl)carbamoyl]-5-methoxy-phenyl]piperidin-4-yl]-1-benzofuran-6-yl]propanoic+acid'>6XQ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kw2 OCA], [https://pdbe.org/5kw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kw2 RCSB], [https://www.ebi.ac.uk/pdbsum/5kw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kw2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/FFAR1_HUMAN FFAR1_HUMAN] Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G-proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway.<ref>PMID:12496284</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5kw2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5kw2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[GPR40|GPR40]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia virus T4]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Baker KA]] | |||
[[Category: Baker | [[Category: Benach J]] | ||
[[Category: Benach | [[Category: Chau B]] | ||
[[Category: Chau | [[Category: Chen Y]] | ||
[[Category: Chen | [[Category: Conners K]] | ||
[[Category: Conners | [[Category: Genin MJ]] | ||
[[Category: Genin | [[Category: Gheyi T]] | ||
[[Category: Gheyi | [[Category: Groshong C]] | ||
[[Category: Groshong | [[Category: Hamdouchi C]] | ||
[[Category: Hamdouchi | [[Category: Ho JD]] | ||
[[Category: Ho | [[Category: Kahl SD]] | ||
[[Category: Kahl | [[Category: Lee MR]] | ||
[[Category: Lee | [[Category: Lewis AP]] | ||
[[Category: Lewis | [[Category: Linswala JP]] | ||
[[Category: Linswala | [[Category: Lu F]] | ||
[[Category: Lu | [[Category: Madsen RE]] | ||
[[Category: Madsen | [[Category: Miller AR]] | ||
[[Category: Miller | [[Category: Montrose-Rafizadeh C]] | ||
[[Category: Montrose-Rafizadeh | [[Category: Otto KA]] | ||
[[Category: Otto | [[Category: Reynolds NA]] | ||
[[Category: Reynolds | [[Category: Riley JP]] | ||
[[Category: Riley | [[Category: Rodgers L]] | ||
[[Category: Rodgers | [[Category: Saflor MD]] | ||
[[Category: Saflor | [[Category: Song M]] | ||
[[Category: Song | [[Category: Wilbur KL]] | ||
[[Category: Wilbur | [[Category: Yang H-C]] | ||
[[Category: Yang | |||