5km6: Difference between revisions

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==Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant Ara-A nucleoside phosphoramidate substrate complex==
==Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant Ara-A nucleoside phosphoramidate substrate complex==
<StructureSection load='5km6' size='340' side='right' caption='[[5km6]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='5km6' size='340' side='right'caption='[[5km6]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5km6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KM6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5km6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KM6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KM6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6US:[(2~{R},3~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]phosphonamidic+acid'>6US</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tw2|3tw2]], [[5ipb|5ipb]], [[5ipc|5ipc]], [[5ipd|5ipd]], [[5ipe|5ipe]], [[5kly|5kly]], [[5klz|5klz]], [[5km0|5km0]], [[5km1|5km1]], [[5km2|5km2]], [[5km3|5km3]], [[5km4|5km4]], [[5km5|5km5]], [[5km7|5km7]], [[5km8|5km8]], [[5km9|5km9]], [[5kma|5kma]], [[5kmb|5kmb]], [[5kmc|5kmc]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6US:[(2~{R},3~{S},4~{S},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[2-(1~{H}-indol-3-yl)ethyl]phosphonamidic+acid'>6US</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HINT1, HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5km6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5km6 OCA], [https://pdbe.org/5km6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5km6 RCSB], [https://www.ebi.ac.uk/pdbsum/5km6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5km6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5km6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5km6 OCA], [http://pdbe.org/5km6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5km6 RCSB], [http://www.ebi.ac.uk/pdbsum/5km6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5km6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).  
[https://www.uniprot.org/uniprot/HINT1_HUMAN HINT1_HUMAN] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2 (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
*[[Histidine triad nucleotide-binding protein 3D structures|Histidine triad nucleotide-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Finzel, B C]]
[[Category: Large Structures]]
[[Category: Maize, K M]]
[[Category: Finzel BC]]
[[Category: Hint]]
[[Category: Maize KM]]
[[Category: Histidine triad]]
[[Category: Hit]]
[[Category: Hydrolase]]

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