4xqr: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4xqr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XQR FirstGlance]. <br> | <table><tr><td colspan='2'>[[4xqr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XQR FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqr OCA], [https://pdbe.org/4xqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xqr RCSB], [https://www.ebi.ac.uk/pdbsum/4xqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqr ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xqr OCA], [https://pdbe.org/4xqr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xqr RCSB], [https://www.ebi.ac.uk/pdbsum/4xqr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xqr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 10:48, 27 September 2023
Crystal structure of unliganded human FPPS at 2.15 angstrom resolutionCrystal structure of unliganded human FPPS at 2.15 angstrom resolution
Structural highlights
FunctionFPPS_HUMAN Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. See Also |
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