5k0b: Difference between revisions

<table><tr><td colspan='2'>[[5k0b]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K0B FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6PS:2,4-DIMETHYL-5-{3-[(1R)-1-PHENYLETHYL]-1H-PYRAZOL-5-YL}-1,3-THIAZOLE'>6PS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k0b OCA], [https://pdbe.org/5k0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k0b RCSB], [https://www.ebi.ac.uk/pdbsum/5k0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k0b ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

[[Category: Rattus norvegicus]]

[[Category: Ehler A]]

[[Category: Rodriguez-Sarmiento RM]]

[[Category: Rudolph MG]]