5jfb: Difference between revisions

<table><tr><td colspan='2'>[[5jfb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JFB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JFB FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD163, M130 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9823 PIG])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jfb OCA], [http://pdbe.org/5jfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jfb RCSB], [http://www.ebi.ac.uk/pdbsum/5jfb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jfb ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/C163A_PIG C163A_PIG]] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.<ref>PMID:14648288</ref>  After shedding, the soluble form (sCD163) may play an anti-inflammatory role.  

[[Category: Pig]]

[[Category: Jiang, L]]

[[Category: Li, R]]

[[Category: Ma, H]]

[[Category: Qiao, S]]

[[Category: Zhang, G]]

[[Category: Srcr]]