1mt6: Difference between revisions

Revision as of 01:41, 3 May 2008

Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy

OverviewOverview

The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.

About this StructureAbout this Structure

1MT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The active site of the SET domain is constructed on a knot., Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S, Nat Struct Biol. 2002 Nov;9(11):833-8. PMID:12389038 Page seeded by OCA on Sat May 3 01:41:24 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1mt6.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1mt6 |SIZE=350|CAPTION= <scene name='initialview01'>1mt6</scene>, resolution 2.20&Aring;
+The line below this paragraph, containing "STRUCTURE_1mt6", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1mt6|  PDB=1mt6  |  SCENE=  }}
-|RELATEDENTRY=[[1muf|1MUF]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mt6 OCA], [http://www.ebi.ac.uk/pdbsum/1mt6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mt6 RCSB]</span>
-}}
 '''Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy'''
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 [[Category: Kim, Y.]]
 [[Category: Rastinejad, F.]]
-[[Category: adohcy]]
+[[Category: Adohcy]]
-[[Category: histone lysine methyltransferase]]
+[[Category: Histone lysine methyltransferase]]
-[[Category: knot]]
+[[Category: Knot]]
-[[Category: set domain]]
+[[Category: Set domain]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:41:24 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:20:47 2008''