3psl: Difference between revisions
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<StructureSection load='3psl' size='340' side='right'caption='[[3psl]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='3psl' size='340' side='right'caption='[[3psl]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3psl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3psl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PSL FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psl OCA], [https://pdbe.org/3psl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3psl RCSB], [https://www.ebi.ac.uk/pdbsum/3psl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3psl ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3psl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3psl OCA], [https://pdbe.org/3psl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3psl RCSB], [https://www.ebi.ac.uk/pdbsum/3psl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3psl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Avdic | [[Category: Avdic V]] | ||
[[Category: Couture | [[Category: Couture J-F]] | ||
[[Category: Lanouette | [[Category: Lanouette S]] | ||
[[Category: Skerjanc | [[Category: Skerjanc I]] | ||
[[Category: Voronova | [[Category: Voronova A]] | ||
[[Category: Zhang | [[Category: Zhang P]] | ||