3ny9: Difference between revisions
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==Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist== | ==Crystal structure of the human beta2 adrenergic receptor in complex with a novel inverse agonist== | ||
<StructureSection load='3ny9' size='340' side='right' caption='[[3ny9]], [[Resolution|resolution]] 2.84Å' scene=''> | <StructureSection load='3ny9' size='340' side='right'caption='[[3ny9]], [[Resolution|resolution]] 2.84Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ny9]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ny9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NY9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JSZ:ETHYL+4-({(2S)-2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPYL}OXY)-3-METHYL-1-BENZOFURAN-2-CARBOXYLATE'>JSZ</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JSZ:ETHYL+4-({(2S)-2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPYL}OXY)-3-METHYL-1-BENZOFURAN-2-CARBOXYLATE'>JSZ</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ny9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny9 OCA], [https://pdbe.org/3ny9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ny9 RCSB], [https://www.ebi.ac.uk/pdbsum/3ny9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny9 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/3ny9_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/3ny9_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]] | |||
*[[Lysozyme 3D structures|Lysozyme 3D structures]] | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia virus T4]] | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Abagyan | [[Category: Large Structures]] | ||
[[Category: Brown | [[Category: Abagyan R]] | ||
[[Category: Cherezov | [[Category: Brown MA]] | ||
[[Category: Fenalti | [[Category: Cherezov V]] | ||
[[Category: Fenalti G]] | |||
[[Category: Katritch | [[Category: Katritch V]] | ||
[[Category: Stevens | [[Category: Stevens RC]] | ||
[[Category: Wacker | [[Category: Wacker D]] | ||