3mnp: Difference between revisions

<StructureSection load='3mnp' size='340' side='right'caption='[[3mnp]], [[Resolution|resolution]] 1.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[3mnp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MNP FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEX:DEXAMETHASONE'>DEX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mnp OCA], [https://pdbe.org/3mnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mnp RCSB], [https://www.ebi.ac.uk/pdbsum/3mnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mnp ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GCR_MOUSE GCR_MOUSE] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.<ref>PMID:21994940</ref>  

*[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]]

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Banner D]]

[[Category: Benz J]]

[[Category: D'Arcy B]]

[[Category: Hennig M]]

[[Category: Ruf A]]

[[Category: Schoch GA]]

[[Category: Seitz T]]

[[Category: Sterner R]]

[[Category: Stihle M]]

[[Category: Thoma R]]