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<StructureSection load='3maz' size='340' side='right'caption='[[3maz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3maz' size='340' side='right'caption='[[3maz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3maz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MAZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3maz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MAZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STAP1, BRDG1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3maz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3maz OCA], [https://pdbe.org/3maz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3maz RCSB], [https://www.ebi.ac.uk/pdbsum/3maz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3maz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3maz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3maz OCA], [https://pdbe.org/3maz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3maz RCSB], [https://www.ebi.ac.uk/pdbsum/3maz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3maz ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/NTAL_HUMAN NTAL_HUMAN]] Williams syndrome. Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.<ref>PMID:11124535</ref> <ref>PMID:11003705</ref> <ref>PMID:11124535</ref> 
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/STAP1_HUMAN STAP1_HUMAN]] In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.<ref>PMID:10518561</ref> [[https://www.uniprot.org/uniprot/NTAL_HUMAN NTAL_HUMAN]] Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.<ref>PMID:12486104</ref> <ref>PMID:12514734</ref> <ref>PMID:15010370</ref> 
[https://www.uniprot.org/uniprot/STAP1_HUMAN STAP1_HUMAN] In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.<ref>PMID:10518561</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Huang, H]]
[[Category: Huang H]]
[[Category: Kaneko, T]]
[[Category: Kaneko T]]
[[Category: Li, L]]
[[Category: Li L]]
[[Category: Li, S S]]
[[Category: Li SS]]
[[Category: Liu, H]]
[[Category: Liu H]]
[[Category: Schiller, M R]]
[[Category: Schiller MR]]
[[Category: Voss, C K]]
[[Category: Voss CK]]
[[Category: Wu, C]]
[[Category: Wu C]]
[[Category: Zhao, B]]
[[Category: Zhao B]]
[[Category: Cytoplasm]]
[[Category: Modular domain]]
[[Category: Phosphoprotein]]
[[Category: Phosphotyrosine]]
[[Category: Sh2 domain]]
[[Category: Signaling protein]]
[[Category: Specificity]]

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