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==Mouse Plasminogen Activator Inhibitor-1 (PAI-1)== | ==Mouse Plasminogen Activator Inhibitor-1 (PAI-1)== | ||
<StructureSection load='3lw2' size='340' side='right' caption='[[3lw2]], [[Resolution|resolution]] 1.93Å' scene=''> | <StructureSection load='3lw2' size='340' side='right'caption='[[3lw2]], [[Resolution|resolution]] 1.93Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3lw2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3lw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LW2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lw2 OCA], [https://pdbe.org/3lw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lw2 RCSB], [https://www.ebi.ac.uk/pdbsum/3lw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lw2 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PAI1_MOUSE PAI1_MOUSE] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lw2_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lw2_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 29: | Line 28: | ||
</div> | </div> | ||
<div class="pdbe-citations 3lw2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3lw2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: | [[Category: Compernolle G]] | ||
[[Category: Declerck | [[Category: Declerck PJ]] | ||
[[Category: Dewilde | [[Category: Dewilde M]] | ||
[[Category: Gils | [[Category: Gils A]] | ||
[[Category: Madsen | [[Category: Madsen JB]] | ||
[[Category: Strelkov | [[Category: Strelkov SV]] | ||
[[Category: | [[Category: Van De Craen B]] | ||