3l25: Difference between revisions

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 <StructureSection load='3l25' size='340' side='right'caption='[[3l25]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3l25]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebov-may Ebov-may]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L25 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3l25]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L25 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fke|3fke]], [[3l26|3l26]], [[3l27|3l27]], [[3l28|3l28]], [[3l29|3l29]], [[3l2a|3l2a]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP35 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=128952 EBOV-May])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l25 OCA], [https://pdbe.org/3l25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l25 RCSB], [https://www.ebi.ac.uk/pdbsum/3l25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l25 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM]] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
+[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Ebov-may]]
+[[Category: Ebola virus - Mayinga, Zaire, 1976]]
 [[Category: Large Structures]]
-[[Category: Amarasinghe, G K]]
+[[Category: Amarasinghe GK]]
-[[Category: Basler, C F]]
+[[Category: Basler CF]]
-[[Category: Borek, D M]]
+[[Category: Borek DM]]
-[[Category: Farahbakhsh, M]]
+[[Category: Farahbakhsh M]]
-[[Category: Helgeson, L A]]
+[[Category: Helgeson LA]]
-[[Category: Honzatko, R B]]
+[[Category: Honzatko RB]]
-[[Category: Leung, D W]]
+[[Category: Leung DW]]
-[[Category: Nix, J C]]
+[[Category: Nix JC]]
-[[Category: Otwinowski, Z]]
+[[Category: Otwinowski Z]]
-[[Category: Prins, K C]]
+[[Category: Prins KC]]
-[[Category: Ramanan, P]]
+[[Category: Ramanan P]]
-[[Category: Tufariello, J M]]
+[[Category: Tufariello JM]]
-[[Category: Coiled coil]]
-[[Category: Host cytoplasm]]
-[[Category: Interferon antiviral system evasion]]
-[[Category: Rna binding domain]]
-[[Category: Rna binding protein]]
-[[Category: Rna binding protein-rna complex]]
-[[Category: Rna replication]]
-[[Category: Rna-binding]]
-[[Category: Transcription]]
-[[Category: Virion]]