3kpv: Difference between revisions

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==Crystal Structure of hPNMT in Complex AdoHcy and Adenine==
==Crystal Structure of hPNMT in Complex AdoHcy and Adenine==
<StructureSection load='3kpv' size='340' side='right' caption='[[3kpv]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3kpv' size='340' side='right'caption='[[3kpv]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3kpv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KPV FirstGlance]. <br>
<table><tr><td colspan='2'>[[3kpv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KPV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kpj|3kpj]], [[3kpu|3kpu]], [[3kpw|3kpw]], [[3kpy|3kpy]], [[3kqm|3kqm]], [[3kqo|3kqo]], [[3kqp|3kqp]], [[3kqq|3kqq]], [[3kqs|3kqs]], [[3kqt|3kqt]], [[3kqv|3kqv]], [[3kqw|3kqw]], [[3kqy|3kqy]], [[3kr0|3kr0]], [[3kr1|3kr1]], [[3kr2|3kr2]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADE:ADENINE'>ADE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PNMT, PENT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpv OCA], [https://pdbe.org/3kpv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kpv RCSB], [https://www.ebi.ac.uk/pdbsum/3kpv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kpv ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kpv OCA], [http://pdbe.org/3kpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kpv RCSB], [http://www.ebi.ac.uk/pdbsum/3kpv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kpv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.  
[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN] Converts noradrenaline to adrenaline.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/3kpv_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/3kpv_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3kpv" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3kpv" style="background-color:#fffaf0;"></div>
==See Also==
*[[Phenylethanolamine N-methyltransferase|Phenylethanolamine N-methyltransferase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Phenylethanolamine N-methyltransferase]]
[[Category: Large Structures]]
[[Category: Drinkwater, N]]
[[Category: Drinkwater N]]
[[Category: Martin, J L]]
[[Category: Martin JL]]
[[Category: Catecholamine biosynthesis]]
[[Category: Fragment screening]]
[[Category: Methyltransferase]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Transferase]]

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