3ki5: Difference between revisions

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 <StructureSection load='3ki5' size='340' side='right'caption='[[3ki5]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3ki5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KI5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3ki5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KI5 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9M:N-(6-OXO-5,6-DIHYDROBENZO[C][1,5]NAPHTHYRIDIN-2-YL)-2-(4-PYRROLIDIN-1-YLPIPERIDIN-1-YL)ACETAMIDE'>G9M</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ess|3ess]], [[2q6m|2q6m]], [[2q5t|2q5t]], [[3ki0|3ki0]], [[3ki1|3ki1]], [[3ki2|3ki2]], [[3ki3|3ki3]], [[3ki4|3ki4]], [[3ki6|3ki6]], [[3ki7|3ki7]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9M:N-(6-OXO-5,6-DIHYDROBENZO[C][1,5]NAPHTHYRIDIN-2-YL)-2-(4-PYRROLIDIN-1-YLPIPERIDIN-1-YL)ACETAMIDE'>G9M</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chxa, toxA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 "Bacillo virgola del Koch" Trevisan 1884])</td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36] </span></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ki5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki5 OCA], [https://pdbe.org/3ki5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ki5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ki5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki5 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>
+[https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>
 ==See Also==
@@ Line 19: / Line 17: @@
 __TOC__
 </StructureSection>
-[[Category: Bacillo virgola del koch trevisan 1884]]
 [[Category: Large Structures]]
-[[Category: Edwards, P R]]
+[[Category: Vibrio cholerae]]
-[[Category: Jorgensen, R]]
+[[Category: Edwards PR]]
-[[Category: Merrill, A R]]
+[[Category: Jorgensen R]]
-[[Category: Adp-ribosyl transferase]]
+[[Category: Merrill AR]]
-[[Category: Alpha-beta complex]]
-[[Category: Diphthamide]]
-[[Category: Toxin]]
-[[Category: Transferase]]