1mq0: Difference between revisions

Revision as of 01:34, 3 May 2008

Crystal Structure of Human Cytidine Deaminase

OverviewOverview

Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137.

About this StructureAbout this Structure

1MQ0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:15689149 Page seeded by OCA on Sat May 3 01:34:40 2008

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OCA

@@ Line 1: / Line 1: @@
 [[Image:1mq0.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1mq0 |SIZE=350|CAPTION= <scene name='initialview01'>1mq0</scene>, resolution 2.40&Aring;
+The line below this paragraph, containing "STRUCTURE_1mq0", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=BRD:1-BETA-RIBOFURANOSYL-1,3-DIAZEPINONE'>BRD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytidine_deaminase Cytidine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.5 3.5.4.5] </span>
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1mq0|  PDB=1mq0  |  SCENE=  }}
-|RELATEDENTRY=[[1jtk|1JTK]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mq0 OCA], [http://www.ebi.ac.uk/pdbsum/1mq0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mq0 RCSB]</span>
-}}
 '''Crystal Structure of Human Cytidine Deaminase'''
@@ Line 29: / Line 26: @@
 [[Category: Fromme, J C.]]
 [[Category: Verdine, G L.]]
-[[Category: amine hydrolase]]
+[[Category: Amine hydrolase]]
-[[Category: anticancer]]
+[[Category: Anticancer]]
-[[Category: chemotherapy]]
+[[Category: Chemotherapy]]
-[[Category: cytidine deaminase]]
+[[Category: Cytidine deaminase]]
-[[Category: diazepinone]]
+[[Category: Diazepinone]]
-[[Category: drug]]
+[[Category: Drug]]
-[[Category: edge-to-face interaction]]
+[[Category: Edge-to-face interaction]]
-[[Category: enzyme]]
+[[Category: Enzyme]]
-[[Category: human]]
+[[Category: Human]]
-[[Category: inhibitor]]
+[[Category: Inhibitor]]
-[[Category: leukemia]]
+[[Category: Leukemia]]
-[[Category: phi-phi interaction]]
+[[Category: Phi-phi interaction]]
-[[Category: protein]]
+[[Category: Protein]]
-[[Category: zinc]]
+[[Category: Zinc]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:34:40 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:19:31 2008''