3hps: Difference between revisions
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<StructureSection load='3hps' size='340' side='right'caption='[[3hps]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='3hps' size='340' side='right'caption='[[3hps]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3hps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3hps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HPS FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COI:2-OXO-4-METHYLPENTANOIC+ACID'>COI</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hps OCA], [https://pdbe.org/3hps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hps RCSB], [https://www.ebi.ac.uk/pdbsum/3hps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hps ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hps OCA], [https://pdbe.org/3hps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hps RCSB], [https://www.ebi.ac.uk/pdbsum/3hps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hps ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/LEU1_MYCTU LEU1_MYCTU] Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Baker | [[Category: Baker EN]] | ||
[[Category: Koon | [[Category: Koon N]] | ||
[[Category: Squire | [[Category: Squire CJ]] | ||
Latest revision as of 10:26, 6 September 2023
Crystal structure of Mycobacterium tuberculosis LeuA complexed with ketoisocaproate (KIC)Crystal structure of Mycobacterium tuberculosis LeuA complexed with ketoisocaproate (KIC)
Structural highlights
FunctionLEU1_MYCTU Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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