3g2f: Difference between revisions

<table><tr><td colspan='2'>[[3g2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G2F FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[https://www.uniprot.org/uniprot/BMPR2_HUMAN BMPR2_HUMAN] Defects in BMPR2 are the cause of primary pulmonary hypertension (PPH1) [MIM:[https://omim.org/entry/178600 178600]. PPH1 is a rare autosomal dominant disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.<ref>PMID:10903931</ref> <ref>PMID:11015450</ref> <ref>PMID:10973254</ref> <ref>PMID:11115378</ref> <ref>PMID:12358323</ref> <ref>PMID:15965979</ref>  Defects in BMPR2 are a cause of pulmonary venoocclusive disease (PVOD) [MIM:[https://omim.org/entry/265450 265450]. PVOD is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with PPH1 has been speculative. The finding of PVOD associated with a BMPR2 mutation reveals a possible pathogenetic connection with PPH1.<ref>PMID:12446270</ref> <ref>PMID:16429395</ref>  

[https://www.uniprot.org/uniprot/BMPR2_HUMAN BMPR2_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

[[Category: Homo sapiens]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Bullock A]]

[[Category: Chaikuad A]]

[[Category: Chalk R]]

[[Category: Edwards AM]]

[[Category: Fedorov O]]

[[Category: Filippakopoulos P]]

[[Category: Keates T]]

[[Category: Knapp S]]

[[Category: Petrie K]]

[[Category: Phillips C]]

[[Category: Pike ACW]]

[[Category: Roos AK]]

[[Category: Salah E]]

[[Category: Thangaratnarajah C]]

[[Category: Weigelt J]]

[[Category: Von Delft F]]