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<StructureSection load='3fbv' size='340' side='right'caption='[[3fbv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='3fbv' size='340' side='right'caption='[[3fbv]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3fbv]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FBV FirstGlance]. <br>
<table><tr><td colspan='2'>[[3fbv]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FBV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APJ:N~2~-1H-BENZIMIDAZOL-5-YL-N~4~-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)PYRIMIDINE-2,4-DIAMINE'>APJ</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APJ:N~2~-1H-BENZIMIDAZOL-5-YL-N~4~-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)PYRIMIDINE-2,4-DIAMINE'>APJ</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IRE1, ERN1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbv OCA], [https://pdbe.org/3fbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fbv RCSB], [https://www.ebi.ac.uk/pdbsum/3fbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fbv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbv OCA], [https://pdbe.org/3fbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fbv RCSB], [https://www.ebi.ac.uk/pdbsum/3fbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fbv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IRE1_YEAST IRE1_YEAST]] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.<ref>PMID:8663458</ref> <ref>PMID:8670804</ref> <ref>PMID:9323131</ref>
[https://www.uniprot.org/uniprot/IRE1_YEAST IRE1_YEAST] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices HAC1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes.<ref>PMID:8663458</ref> <ref>PMID:8670804</ref> <ref>PMID:9323131</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Egea, P F]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Finer-Moore, J]]
[[Category: Egea PF]]
[[Category: Korennykh, A V]]
[[Category: Finer-Moore J]]
[[Category: Korostelev, A A]]
[[Category: Korennykh AV]]
[[Category: Shokat, K M]]
[[Category: Korostelev AA]]
[[Category: Stroud, R M]]
[[Category: Shokat KM]]
[[Category: Walter, P]]
[[Category: Stroud RM]]
[[Category: Zhang, C]]
[[Category: Walter P]]
[[Category: Aminopyrazole]]
[[Category: Zhang C]]
[[Category: Apy29]]
[[Category: Atp-binding]]
[[Category: Complex]]
[[Category: Cytoplasmic]]
[[Category: Endoplasmic reticulum]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Inhibitor]]
[[Category: Ire1]]
[[Category: Kinase]]
[[Category: Magnesium]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Multifunctional enzyme]]
[[Category: Nucleotide-binding]]
[[Category: Oligomer]]
[[Category: Phosphoprotein]]
[[Category: Ribonuclease]]
[[Category: Rnase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transferase]]
[[Category: Transmembrane]]
[[Category: Unfolded protein response]]

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