7wm4: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7wm4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WM4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7wm4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WM4 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wm4 OCA], [https://pdbe.org/7wm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wm4 RCSB], [https://www.ebi.ac.uk/pdbsum/7wm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wm4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wm4 OCA], [https://pdbe.org/7wm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wm4 RCSB], [https://www.ebi.ac.uk/pdbsum/7wm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wm4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Revision as of 16:14, 30 August 2023
Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp)Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp)
Structural highlights
FunctionTLR3_MOUSE Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).[1] References
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