3egb: Difference between revisions

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 <StructureSection load='3egb' size='340' side='right'caption='[[3egb]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3egb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EGB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3egb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EGB FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ega|3ega]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PELI2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3egb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3egb OCA], [https://pdbe.org/3egb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3egb RCSB], [https://www.ebi.ac.uk/pdbsum/3egb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3egb ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/PELI2_HUMAN PELI2_HUMAN]] E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<ref>PMID:12804775</ref> <ref>PMID:12860405</ref> <ref>PMID:17675297</ref> <ref>PMID:17997719</ref> <ref>PMID:22669975</ref>
+[https://www.uniprot.org/uniprot/PELI2_HUMAN PELI2_HUMAN] E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<ref>PMID:12804775</ref> <ref>PMID:12860405</ref> <ref>PMID:17675297</ref> <ref>PMID:17997719</ref> <ref>PMID:22669975</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Ferguson, K M]]
+[[Category: Ferguson KM]]
-[[Category: Lin, C]]
+[[Category: Lin C]]
-[[Category: Schmitz, K R]]
+[[Category: Schmitz KR]]
-[[Category: E3 ubiquitin ligase]]
-[[Category: Fha domain]]
-[[Category: Pellino]]
-[[Category: Phosphoprotein]]
-[[Category: Protein binding]]
-[[Category: Substrate binding domain]]