3e77: Difference between revisions

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<StructureSection load='3e77' size='340' side='right'caption='[[3e77]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3e77' size='340' side='right'caption='[[3e77]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3e77]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E77 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3e77]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E77 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PSAT1, PSA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoserine_transaminase Phosphoserine transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.52 2.6.1.52] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e77 OCA], [https://pdbe.org/3e77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e77 RCSB], [https://www.ebi.ac.uk/pdbsum/3e77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e77 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e77 OCA], [https://pdbe.org/3e77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e77 RCSB], [https://www.ebi.ac.uk/pdbsum/3e77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e77 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/SERC_HUMAN SERC_HUMAN]] Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:[https://omim.org/entry/610992 610992]]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.<ref>PMID:17436247</ref>
[https://www.uniprot.org/uniprot/SERC_HUMAN SERC_HUMAN] Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:[https://omim.org/entry/610992 610992]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.<ref>PMID:17436247</ref>  
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SERC_HUMAN SERC_HUMAN]] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine (By similarity).  
[https://www.uniprot.org/uniprot/SERC_HUMAN SERC_HUMAN] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphoserine transaminase]]
[[Category: Andersson J]]
[[Category: Andersson, J]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H]]
[[Category: Berglund H]]
[[Category: Berg, S Van Den]]
[[Category: Bountra C]]
[[Category: Berglund, H]]
[[Category: Collins R]]
[[Category: Bountra, C]]
[[Category: Dahlgren LG]]
[[Category: Collins, R]]
[[Category: Edwards AM]]
[[Category: Dahlgren, L G]]
[[Category: Flodin S]]
[[Category: Edwards, A M]]
[[Category: Flores A]]
[[Category: Flodin, S]]
[[Category: Graslund S]]
[[Category: Flores, A]]
[[Category: Hammarstrom M]]
[[Category: Graslund, S]]
[[Category: Johansson A]]
[[Category: Hammarstrom, M]]
[[Category: Johansson I]]
[[Category: Johansson, A]]
[[Category: Karlberg T]]
[[Category: Johansson, I]]
[[Category: Kotenyova T]]
[[Category: Karlberg, T]]
[[Category: Lehtio L]]
[[Category: Kotenyova, T]]
[[Category: Moche M]]
[[Category: Lehtio, L]]
[[Category: Nilsson ME]]
[[Category: Moche, M]]
[[Category: Nordlund P]]
[[Category: Nilsson, M E]]
[[Category: Nyman T]]
[[Category: Nordlund, P]]
[[Category: Olesen K]]
[[Category: Nyman, T]]
[[Category: Persson C]]
[[Category: Olesen, K]]
[[Category: Sagemark J]]
[[Category: Persson, C]]
[[Category: Schueler H]]
[[Category: Structural genomic]]
[[Category: Thorsell SG]]
[[Category: Sagemark, J]]
[[Category: Tresaugues L]]
[[Category: Schueler, H]]
[[Category: Van Den Berg S]]
[[Category: Thorsell, S G]]
[[Category: Weigelt J]]
[[Category: Tresaugues, L]]
[[Category: Welin M]]
[[Category: Weigelt, J]]
[[Category: Wikstrom M]]
[[Category: Welin, M]]
[[Category: Wisniewska M]]
[[Category: Wikstrom, M]]
[[Category: Wisniewska, M]]
[[Category: Amino-acid biosynthesis]]
[[Category: Aminotransferase]]
[[Category: Disease mutation]]
[[Category: Phosphoserine aminotransferase]]
[[Category: Plp]]
[[Category: Pyridoxal phosphate]]
[[Category: Serc]]
[[Category: Serine biosynthesis]]
[[Category: Sgc]]
[[Category: Transferase]]

Latest revision as of 15:59, 30 August 2023

Human phosphoserine aminotransferase in complex with PLPHuman phosphoserine aminotransferase in complex with PLP

Structural highlights

3e77 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

SERC_HUMAN Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:610992. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.[1]

Function

SERC_HUMAN Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Hart CE, Race V, Achouri Y, Wiame E, Sharrard M, Olpin SE, Watkinson J, Bonham JR, Jaeken J, Matthijs G, Van Schaftingen E. Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway. Am J Hum Genet. 2007 May;80(5):931-7. Epub 2007 Mar 30. PMID:17436247 doi:S0002-9297(07)60948-3

3e77, resolution 2.50Å

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OCA
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