3e4c: Difference between revisions
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<StructureSection load='3e4c' size='340' side='right'caption='[[3e4c]], [[Resolution|resolution]] 2.05Å' scene=''> | <StructureSection load='3e4c' size='340' side='right'caption='[[3e4c]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3e4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3e4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E4C FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id=' | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e4c OCA], [https://pdbe.org/3e4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e4c RCSB], [https://www.ebi.ac.uk/pdbsum/3e4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e4c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e4c OCA], [https://pdbe.org/3e4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e4c RCSB], [https://www.ebi.ac.uk/pdbsum/3e4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e4c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Elliott | [[Category: Elliott JM]] | ||
[[Category: Rouge | [[Category: Rouge L]] | ||
[[Category: Scheer | [[Category: Scheer JM]] | ||
[[Category: Wiesmann | [[Category: Wiesmann C]] | ||