3dl2: Difference between revisions

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 <StructureSection load='3dl2' size='340' side='right'caption='[[3dl2]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3dl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DL2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3dl2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DL2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2i6t|2i6t]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UEVLD, UEV3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dl2 OCA], [https://pdbe.org/3dl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dl2 RCSB], [https://www.ebi.ac.uk/pdbsum/3dl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dl2 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/UEVLD_HUMAN UEVLD_HUMAN]] Possible negative regulator of polyubiquitination.<ref>PMID:12427560</ref>
+[https://www.uniprot.org/uniprot/UEVLD_HUMAN UEVLD_HUMAN] Possible negative regulator of polyubiquitination.<ref>PMID:12427560</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dl2 ConSurf].
 <div style="clear:both"></div>
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-Recent studies have shown that ubiquitination is an essential factor in endosomal sorting and virus assembly. The human TSG101 gene has been demonstrated to belong to a group of genes coding for apparently inactive E2 ubiquitin-conjugating enzymes, which exert regulatory effects on E2 activity in cellular ubiquitination processes. In this study, a novel human cDNA (UEV3) encoding a putative protein of 379 amino acids was isolated from a human placenta library that may represent a partial paralogue of human TSG101. The predicted protein contains an N-terminal domain homologous to the catalytic domain of ubiquitin-conjugating enzymes (Ubc), which is fused to a sequence showing significant homology to members of the lactate dehydrogenase protein family. The UEV3 gene is located on chromosome 11 closely adjacent to TSG101 and LDH-C. Northern blot and UEV3-specific reverse transcription/polymerase chain reaction (RT/PCR) analyses of various colon carcinoma cell lines as well as both normal and tumor samples from colon revealed an expression of the UEV3 cDNA in all tested samples.
-Identification and characterization of UEV3, a human cDNA with similarities to inactive E2 ubiquitin-conjugating enzymes.,Kloor M, Bork P, Duwe A, Klaes R, von Knebel Doeberitz M, Ridder R Biochim Biophys Acta. 2002 Dec 12;1579(2-3):219-24. PMID:12427560<ref>PMID:12427560</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 3dl2" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Arrowsmith, C H]]
+[[Category: Arrowsmith CH]]
-[[Category: Avvakumov, G V]]
+[[Category: Avvakumov GV]]
-[[Category: Bochkarev, A]]
+[[Category: Bochkarev A]]
-[[Category: Bountra, C]]
+[[Category: Bountra C]]
-[[Category: Butler-Cole, C]]
+[[Category: Butler-Cole C]]
-[[Category: Dhe-Paganon, S]]
+[[Category: Dhe-Paganon S]]
-[[Category: Edwards, A M]]
+[[Category: Edwards AM]]
-[[Category: Finerty, P J]]
+[[Category: Finerty Jr PJ]]
-[[Category: Newman, E M]]
+[[Category: Newman EM]]
-[[Category: Structural genomic]]
+[[Category: Walker JR]]
-[[Category: Walker, J R]]
+[[Category: Wolkstrom M]]
-[[Category: Wolkstrom, M]]
+[[Category: Xue S]]
-[[Category: Xue, S]]
-[[Category: Alternative splicing]]
-[[Category: L-lactate dehydrogenase]]
-[[Category: Nad]]
-[[Category: Oxidoreductase]]
-[[Category: Sgc]]
-[[Category: Ubiquitin-protein ligase]]
-[[Category: Ubl conjugation pathway]]
-[[Category: Unknown function]]