1mk7: Difference between revisions

Revision as of 01:16, 3 May 2008

CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA

OverviewOverview

The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior.

About this StructureAbout this Structure

1MK7 is a Protein complex structure of sequences from Gallus gallus and Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Structural determinants of integrin recognition by talin., Garcia-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC, Mol Cell. 2003 Jan;11(1):49-58. PMID:12535520 Page seeded by OCA on Sat May 3 01:16:07 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1mk7.gif|left|200px]]
- {{Structure
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mk7 OCA], [http://www.ebi.ac.uk/pdbsum/1mk7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mk7 RCSB]</span>
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 '''CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA'''
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 [[Category: Pereda, J M.De.]]
 [[Category: Ulmer, T S.]]
-[[Category: cytoskeleton]]
+[[Category: Cytoskeleton]]
-[[Category: ferm domain]]
+[[Category: Ferm domain]]
-[[Category: focal adhesion]]
+[[Category: Focal adhesion]]
-[[Category: integrin binding]]
+[[Category: Integrin binding]]
-[[Category: npxy motif]]
+[[Category: Npxy motif]]
-[[Category: ptb domain]]
+[[Category: Ptb domain]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:16:07 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:17:06 2008''