2qs2: Difference between revisions
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<StructureSection load='2qs2' size='340' side='right'caption='[[2qs2]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2qs2' size='340' side='right'caption='[[2qs2]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2qs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2qs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QS2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UBF:3-({3-[(2S)-2-AMINO-2-CARBOXYETHYL]-5-BROMO-2,6-DIOXO-3,6-DIHYDROPYRIMIDIN-1(2H)-YL}METHYL)THIOPHENE-2-CARBOXYLIC+ACID'>UBF</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UBF:3-({3-[(2S)-2-AMINO-2-CARBOXYETHYL]-5-BROMO-2,6-DIOXO-3,6-DIHYDROPYRIMIDIN-1(2H)-YL}METHYL)THIOPHENE-2-CARBOXYLIC+ACID'>UBF</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qs2 OCA], [https://pdbe.org/2qs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qs2 RCSB], [https://www.ebi.ac.uk/pdbsum/2qs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qs2 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qs2 OCA], [https://pdbe.org/2qs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qs2 RCSB], [https://www.ebi.ac.uk/pdbsum/2qs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qs2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/GRIK1_RAT GRIK1_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.<ref>PMID:16540562</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: | [[Category: Alushin GM]] | ||
[[Category: | [[Category: Jane DE]] | ||
[[Category: | [[Category: Mayer ML]] | ||