2pla: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='2pla' size='340' side='right'caption='[[2pla]], [[Resolution|resolution]] 2.51Å' scene=''> | <StructureSection load='2pla' size='340' side='right'caption='[[2pla]], [[Resolution|resolution]] 2.51Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2pla]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2pla]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PLA FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pla OCA], [https://pdbe.org/2pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pla RCSB], [https://www.ebi.ac.uk/pdbsum/2pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pla ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pla OCA], [https://pdbe.org/2pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pla RCSB], [https://www.ebi.ac.uk/pdbsum/2pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pla ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/GPD1L_HUMAN GPD1L_HUMAN] Brugada syndrome. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/GPD1L_HUMAN GPD1L_HUMAN] Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.<ref>PMID:19666841</ref> <ref>PMID:19745168</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 26: | Line 26: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bunkoczi | [[Category: Bunkoczi G]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Hozjan V]] | ||
[[Category: Hozjan | [[Category: Kavanagh K]] | ||
[[Category: Kavanagh | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Papagrigoriou E]] | ||
[[Category: Papagrigoriou | [[Category: Pike ACW]] | ||
[[Category: Pike | [[Category: Smee C]] | ||
[[Category: Sundstrom M]] | |||
[[Category: Smee | [[Category: Ugochukwu E]] | ||
[[Category: Sundstrom | [[Category: Umeano C]] | ||
[[Category: Ugochukwu | [[Category: Uppenberg J]] | ||
[[Category: Umeano | [[Category: Weigelt J]] | ||
[[Category: Uppenberg | [[Category: Von Delft F]] | ||
[[Category: Weigelt | |||
[[Category: | |||
Latest revision as of 14:04, 30 August 2023
Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like proteinCrystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein
Structural highlights
DiseaseGPD1L_HUMAN Brugada syndrome. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. FunctionGPD1L_HUMAN Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.[1] [2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
|
| ||||||||||||||||||