2p6x: Difference between revisions
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<StructureSection load='2p6x' size='340' side='right'caption='[[2p6x]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='2p6x' size='340' side='right'caption='[[2p6x]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2p6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2p6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P6X FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id=' | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p6x OCA], [https://pdbe.org/2p6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p6x RCSB], [https://www.ebi.ac.uk/pdbsum/2p6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p6x ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p6x OCA], [https://pdbe.org/2p6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p6x RCSB], [https://www.ebi.ac.uk/pdbsum/2p6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p6x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[https://omim.org/entry/152700 152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref> | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN] Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<ref>PMID:16461343</ref> <ref>PMID:18056643</ref> <ref>PMID:19167335</ref> <ref>PMID:21719704</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Alfano I]] | |||
[[Category: Alfano | [[Category: Arrowsmith CH]] | ||
[[Category: Arrowsmith | [[Category: Barr A]] | ||
[[Category: Barr | [[Category: Bunkoczi G]] | ||
[[Category: Bunkoczi | [[Category: Burgess-Brown N]] | ||
[[Category: Burgess-Brown | [[Category: Edwards A]] | ||
[[Category: King O]] | |||
[[Category: Edwards | [[Category: Knapp S]] | ||
[[Category: King | [[Category: Papagrigoriou E]] | ||
[[Category: Knapp | [[Category: Pike ACW]] | ||
[[Category: Papagrigoriou | [[Category: Salah E]] | ||
[[Category: Pike | [[Category: Shrestha L]] | ||
[[Category: Sundstrom M]] | |||
[[Category: Salah | [[Category: Turnbull A]] | ||
[[Category: Shrestha | [[Category: Ugochukwu E]] | ||
[[Category: Sundstrom | [[Category: Umeano C]] | ||
[[Category: Turnbull | [[Category: Uppenberg J]] | ||
[[Category: Ugochukwu | [[Category: Weigelt J]] | ||
[[Category: Umeano | [[Category: Von Delft F]] | ||
[[Category: Uppenberg | |||
[[Category: Weigelt | |||
[[Category: | |||