2p31: Difference between revisions

<table><tr><td colspan='2'>[[2p31]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P31 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GPX7, GPX6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_peroxidase Glutathione peroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.9 1.11.1.9] </span></td></tr>

[[https://www.uniprot.org/uniprot/GPX7_HUMAN GPX7_HUMAN]] Defects in GPX7 are a cause of Barrett esophagus (BE) [MIM:[https://omim.org/entry/614266 614266]]. A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Note=The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells.  

[[https://www.uniprot.org/uniprot/GPX7_HUMAN GPX7_HUMAN]] It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.  

[[Category: Glutathione peroxidase]]

[[Category: Human]]

[[Category: Arrowsmith, C H]]

[[Category: Delft, F von]]

[[Category: Edwards, A]]

[[Category: Gileadi, O]]

[[Category: Johansson, C]]

[[Category: Kavanagh, K L]]

[[Category: Kochan, G]]

[[Category: Oppermann, U]]

[[Category: Papagrigoriou, E]]

[[Category: Structural genomic]]

[[Category: Sundstrom, M]]

[[Category: Umeano, C]]

[[Category: Weigelt, J]]

[[Category: Npgpx]]

[[Category: Thioredoxin fold]]