2o0r: Difference between revisions
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<StructureSection load='2o0r' size='340' side='right'caption='[[2o0r]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2o0r' size='340' side='right'caption='[[2o0r]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2o0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2o0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O0R FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o0r OCA], [https://pdbe.org/2o0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o0r RCSB], [https://www.ebi.ac.uk/pdbsum/2o0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o0r ProSAT], [https://www.topsan.org/Proteins/TBSGC/2o0r TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o0r OCA], [https://pdbe.org/2o0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o0r RCSB], [https://www.ebi.ac.uk/pdbsum/2o0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o0r ProSAT], [https://www.topsan.org/Proteins/TBSGC/2o0r TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DAPC_MYCTU DAPC_MYCTU] Involved in the lysine biosynthetic pathways. It catalyzes the transfer of an amino group from L-glutamate to N-succinyl-2-l-amino-6-oxoheptanedioate (N-succinyl-2-l-amino-6-ketopimelate) in a PLP-dependent reaction, yielding as products N-succinyl-l-2,6-diaminoheptanedioate (N-succinyl-diaminopimelate) and 2-oxoglutarate (Probable).<ref>PMID:17292400</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Kefala | [[Category: Kefala G]] | ||
[[Category: Weiss MS]] | |||
[[Category: Weiss | [[Category: Weyand S]] | ||
[[Category: Weyand | |||