2h04: Difference between revisions
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<StructureSection load='2h04' size='340' side='right'caption='[[2h04]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2h04' size='340' side='right'caption='[[2h04]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2h04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2h04]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H04 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4UN:{4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC+ACID'>4UN</scene></td></tr> | |||
<tr id=' | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h04 OCA], [https://pdbe.org/2h04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h04 RCSB], [https://www.ebi.ac.uk/pdbsum/2h04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h04 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h04 OCA], [https://pdbe.org/2h04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h04 RCSB], [https://www.ebi.ac.uk/pdbsum/2h04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h04 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PTPRB_HUMAN PTPRB_HUMAN] Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).<ref>PMID:19116766</ref> <ref>PMID:19136612</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Amarasinghe KD]] | |||
[[Category: Amarasinghe | [[Category: Clark CM]] | ||
[[Category: Clark | [[Category: Evdokimov AG]] | ||
[[Category: Evdokimov | [[Category: Gray JL]] | ||
[[Category: Gray | [[Category: Maier MB]] | ||
[[Category: Maier | [[Category: Mekel M]] | ||
[[Category: Mekel | [[Category: Nichols R]] | ||
[[Category: Nichols | [[Category: Peters KG]] | ||
[[Category: Peters | [[Category: Pokross ME]] | ||
[[Category: Pokross | [[Category: Walter RL]] | ||
[[Category: Walter | |||