1me3: Difference between revisions

Revision as of 00:55, 3 May 2008

High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)

OverviewOverview

The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.

About this StructureAbout this Structure

1ME3 is a Single protein structure of sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain., Huang L, Brinen LS, Ellman JA, Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703 Page seeded by OCA on Sat May 3 00:55:57 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1me3.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1me3 |SIZE=350|CAPTION= <scene name='initialview01'>1me3</scene>, resolution 1.2&Aring;
+The line below this paragraph, containing "STRUCTURE_1me3", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=P10:[1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC+ACID+PYRIDIN-4-YLMETHYL+ESTER'>P10</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1me3|  PDB=1me3  |  SCENE=  }}
-|RELATEDENTRY=[[1f29|1f29]], [[1f2a|1f2a]], [[1f2b|1f2b]], [[1f2c|1f2c]], [[1me4|1me4]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1me3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1me3 OCA], [http://www.ebi.ac.uk/pdbsum/1me3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1me3 RCSB]</span>
-}}
 '''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)'''
@@ Line 28: / Line 25: @@
 [[Category: Ellman, J A.]]
 [[Category: Huang, L.]]
-[[Category: cysteine protease]]
+[[Category: Cysteine protease]]
-[[Category: non-covalent inhibitor]]
+[[Category: Non-covalent inhibitor]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:55:57 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:14:57 2008''