2xvt: Difference between revisions

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<StructureSection load='2xvt' size='340' side='right'caption='[[2xvt]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='2xvt' size='340' side='right'caption='[[2xvt]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xvt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVT FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xvt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvt OCA], [https://pdbe.org/2xvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvt RCSB], [https://www.ebi.ac.uk/pdbsum/2xvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvt OCA], [https://pdbe.org/2xvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvt RCSB], [https://www.ebi.ac.uk/pdbsum/2xvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RAMP2_HUMAN RAMP2_HUMAN]] Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.<ref>PMID:22102369</ref> <ref>PMID:9620797</ref>
[https://www.uniprot.org/uniprot/RAMP2_HUMAN RAMP2_HUMAN] Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.<ref>PMID:22102369</ref> <ref>PMID:9620797</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Barr, A J]]
[[Category: Barr AJ]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown N]]
[[Category: Canning, P]]
[[Category: Canning P]]
[[Category: Carpenter, E P]]
[[Category: Carpenter EP]]
[[Category: Chaikuad, A]]
[[Category: Chaikuad A]]
[[Category: Das, S]]
[[Category: Das S]]
[[Category: Delft, F von]]
[[Category: Edwards AM]]
[[Category: Edwards, A M]]
[[Category: Goubin S]]
[[Category: Goubin, S]]
[[Category: Kim J]]
[[Category: Kim, J]]
[[Category: Krojer T]]
[[Category: Krojer, T]]
[[Category: Muniz JRC]]
[[Category: Muniz, J R.C]]
[[Category: Pike ACW]]
[[Category: Pike, A C.W]]
[[Category: Quigley A]]
[[Category: Quigley, A]]
[[Category: Shrestha L]]
[[Category: Shrestha, L]]
[[Category: Vollmar M]]
[[Category: Vollmar, M]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Von Delft F]]
[[Category: Adrenomedulin]]
[[Category: Cgrp]]
[[Category: Crlr]]
[[Category: Gpcr]]
[[Category: Membrane protein]]
[[Category: Protein-trafficking]]
[[Category: Receptor transport]]
[[Category: Transmembrane]]

Latest revision as of 11:04, 23 August 2023

Structure of the extracellular domain of human RAMP2Structure of the extracellular domain of human RAMP2

Structural highlights

2xvt is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RAMP2_HUMAN Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.[1] [2]

References

  1. ↑ Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Okuda K, Sakamoto K, Shirouzu M, Shindo T, Yokoyama S. Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. Protein Sci. 2012 Feb;21(2):199-210. doi: 10.1002/pro.2003. Epub 2011 Dec 28. PMID:22102369 doi:10.1002/pro.2003
  2. ↑ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. PMID:9620797 doi:10.1038/30666

2xvt, resolution 2.05Å

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