1ma9: Difference between revisions

Revision as of 00:49, 3 May 2008

Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin

OverviewOverview

The multifunctional vitamin D binding protein (DBP) is an actin-sequestering protein present in blood. The crystal structure of the actin-DBP complex was determined at 2.4 A resolution. DBP binds to actin subdomains 1 and 3 and occludes the cleft at the interface between these subdomains. Most remarkably, DBP demonstrates an unusually large actin-binding interface, far exceeding the binding-interface areas reported for other actin-binding proteins such as profilin, DNase I and gelsolin. The fast-growing side of actin monomers is blocked completely through a perfect structural fit with DBP, demonstrating how DBP effectively interferes with actin-filament formation. It establishes DBP as the hitherto best actin-sequestering protein and highlights its key role in suppressing and preventing extracellular actin polymerization.

About this StructureAbout this Structure

1MA9 is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

ReferenceReference

Actin-DBP: the perfect structural fit?, Verboven C, Bogaerts I, Waelkens E, Rabijns A, Van Baelen H, Bouillon R, De Ranter C, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):263-73. Epub 2003, Jan 23. PMID:12554937 Page seeded by OCA on Sat May 3 00:49:15 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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- {{Structure
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-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ma9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ma9 OCA], [http://www.ebi.ac.uk/pdbsum/1ma9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ma9 RCSB]</span>
-}}
 '''Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin'''
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 [[Category: Verboven, C.]]
 [[Category: Waelkens, E.]]
-[[Category: actin scavenger system]]
+[[Category: Actin scavenger system]]
-[[Category: complex formed in plasma]]
+[[Category: Complex formed in plasma]]
-[[Category: protein-protein complex]]
+[[Category: Protein-protein complex]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:49:15 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:13:32 2008''