1u90: Difference between revisions

<table><tr><td colspan='2'>[[1u90]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cotton-top_tamarin Cotton-top tamarin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U90 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1U90 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1u8y|1u8y]], [[1u8z|1u8z]]</div></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rala, Ral-a, Ral ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9490 Cotton-top tamarin])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1u90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u90 OCA], [http://pdbe.org/1u90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u90 RCSB], [http://www.ebi.ac.uk/pdbsum/1u90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u90 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/RALA_SAGOE RALA_SAGOE]] Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity).  

[[Category: Kosak, J]]

[[Category: Mattos, C]]

[[Category: Nicely, N I]]

[[Category: Serrano, V de]]

[[Category: Signaling protein]]