1u3h: Difference between revisions
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<StructureSection load='1u3h' size='340' side='right'caption='[[1u3h]], [[Resolution|resolution]] 2.42Å' scene=''> | <StructureSection load='1u3h' size='340' side='right'caption='[[1u3h]], [[Resolution|resolution]] 2.42Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1u3h]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3H FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [https://pdbe.org/1u3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [https://www.ebi.ac.uk/pdbsum/1u3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3h ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3h OCA], [https://pdbe.org/1u3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3h RCSB], [https://www.ebi.ac.uk/pdbsum/1u3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q5R1B3_MOUSE Q5R1B3_MOUSE] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[MHC 3D structures|MHC 3D structures]] | *[[MHC 3D structures|MHC 3D structures]] | ||
*[[MHC II 3D structures|MHC II 3D structures]] | |||
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]] | *[[T-cell receptor 3D structures|T-cell receptor 3D structures]] | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Adams | [[Category: Synthetic construct]] | ||
[[Category: Blondelle | [[Category: Adams EJ]] | ||
[[Category: Boulanger | [[Category: Blondelle SE]] | ||
[[Category: Garcia | [[Category: Boulanger MJ]] | ||
[[Category: Maynard | [[Category: Garcia KC]] | ||
[[Category: Petersson | [[Category: Maynard J]] | ||
[[Category: Wilson | [[Category: Petersson K]] | ||
[[Category: Wilson | [[Category: Wilson DB]] | ||
[[Category: Wilson DH]] | |||
Revision as of 09:37, 23 August 2023
Crystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 ACrystal structure of mouse TCR 172.10 complexed with MHC class II I-Au molecule at 2.4 A
Structural highlights
FunctionEvolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedT cell receptor crossreactivity with different peptide ligands and biased recognition of MHC are coupled features of antigen recognition that are necessary for the T cell's diverse functional repertoire. In the crystal structure between an autoreactive, EAE T cell clone 172.10 and myelin basic protein (1-11) presented by class II MHC I-Au, recognition of the MHC is dominated by the Vbeta domain of the TCR, which interacts with the MHC alpha chain in a manner suggestive of a germline-encoded TCR/MHC "anchor point." Strikingly, there are few specific contacts between the TCR CDR3 loops and the MBP peptide. We also find that over 1,000,000 different peptides derived from combinatorial libraries can activate 172.10, yet the TCR strongly prefers the native MBP contact residues. We suggest that while TCR scanning of pMHC may be degenerate due to the TCR germline bias for MHC, recognition of structurally distinct agonist peptides is not indicative of TCR promiscuity, but rather highly specific alternative solutions to TCR engagement. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.,Maynard J, Petersson K, Wilson DH, Adams EJ, Blondelle SE, Boulanger MJ, Wilson DB, Garcia KC Immunity. 2005 Jan;22(1):81-92. PMID:15664161[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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