1szo: Difference between revisions
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='1szo' size='340' side='right'caption='[[1szo]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1szo' size='340' side='right'caption='[[1szo]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1szo]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp. | <table><tr><td colspan='2'>[[1szo]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_sp._NCIMB_9784 Rhodococcus sp. NCIMB 9784]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZO FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CAX:(2S,4S)-4-(2,2-DIHYDROXYETHYL)-2,3,3-TRIMETHYLCYCLOPENTANONE'>CAX</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1szo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szo OCA], [https://pdbe.org/1szo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1szo RCSB], [https://www.ebi.ac.uk/pdbsum/1szo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1szo ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1szo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szo OCA], [https://pdbe.org/1szo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1szo RCSB], [https://www.ebi.ac.uk/pdbsum/1szo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1szo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CAMK_RHOSO CAMK_RHOSO] Catalyzes the carbon-carbon bond cleavage of the bicyclic beta-diketone 6-oxocamphor via a retro-Claisen reaction to yield the optically active (2R,4S)-beta-campholinic acid. It is also able to cleave 2,2-disubstituted cyclohexa-1,3-diones such as 2-methyl-2-propylcyclohexa-1,3-dione and 2-methyl-2-butylcyclohexa-1,3-dione which result in racemic keto acid products. Transformations of the bicyclic diketone substrates bicyclo[2.2.1]heptane 2,6-dione and bicyclo[2.2.2]octane-2,6-dione yield (S)-keto acid products.<ref>PMID:11278926</ref> <ref>PMID:15138275</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 34: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Rhodococcus sp. | [[Category: Rhodococcus sp. NCIMB 9784]] | ||
[[Category: Grogan | [[Category: Grogan G]] | ||
[[Category: Leonard | [[Category: Leonard PM]] | ||